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COMSOL Inc shear stress simulation plots
Lymph Fluid Flow Profiles Were Estimated in Quiescent and Remodeled LNs To model the affect of lymphatic remodeling or inflammation on the ability of a circulating cell to adhere to SCS-lining cells (A), a simplified geometric model of an afferent lymphatic vessel leading into the LN SCS (B) was imported into COMSOL to perform fluid flow simulations quantifying the wall <t>shear</t> <t>stress</t> (WSS) profile along the SCS floor (solid line) (C). This COMSOL-generated WSS estimation was in close agreement to the analytical solution for WSS profiles in a radial flow chamber (dashed line). (D–G) The analytically calculated ranges of WSS levels for (D, F) human or (E, G) mouse LNs based on maximum and minimum literature cited parameters for (D, E) volumetric flow rate or (F, G) SCS height. (H and I) COMSOL shear stress <t>simulation</t> <t>plots</t> along the (H) floor of the subcapsular sinus or (I) Z-plane of the radial flow chamber LN model.
Shear Stress Simulation Plots, supplied by COMSOL Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "Lymph Node Subcapsular Sinus Microenvironment-On-A-Chip Modeling Shear Flow Relevant to Lymphatic Metastasis and Immune Cell Homing"

Article Title: Lymph Node Subcapsular Sinus Microenvironment-On-A-Chip Modeling Shear Flow Relevant to Lymphatic Metastasis and Immune Cell Homing

Journal: iScience

doi: 10.1016/j.isci.2020.101751

Lymph Fluid Flow Profiles Were Estimated in Quiescent and Remodeled LNs To model the affect of lymphatic remodeling or inflammation on the ability of a circulating cell to adhere to SCS-lining cells (A), a simplified geometric model of an afferent lymphatic vessel leading into the LN SCS (B) was imported into COMSOL to perform fluid flow simulations quantifying the wall shear stress (WSS) profile along the SCS floor (solid line) (C). This COMSOL-generated WSS estimation was in close agreement to the analytical solution for WSS profiles in a radial flow chamber (dashed line). (D–G) The analytically calculated ranges of WSS levels for (D, F) human or (E, G) mouse LNs based on maximum and minimum literature cited parameters for (D, E) volumetric flow rate or (F, G) SCS height. (H and I) COMSOL shear stress simulation plots along the (H) floor of the subcapsular sinus or (I) Z-plane of the radial flow chamber LN model.
Figure Legend Snippet: Lymph Fluid Flow Profiles Were Estimated in Quiescent and Remodeled LNs To model the affect of lymphatic remodeling or inflammation on the ability of a circulating cell to adhere to SCS-lining cells (A), a simplified geometric model of an afferent lymphatic vessel leading into the LN SCS (B) was imported into COMSOL to perform fluid flow simulations quantifying the wall shear stress (WSS) profile along the SCS floor (solid line) (C). This COMSOL-generated WSS estimation was in close agreement to the analytical solution for WSS profiles in a radial flow chamber (dashed line). (D–G) The analytically calculated ranges of WSS levels for (D, F) human or (E, G) mouse LNs based on maximum and minimum literature cited parameters for (D, E) volumetric flow rate or (F, G) SCS height. (H and I) COMSOL shear stress simulation plots along the (H) floor of the subcapsular sinus or (I) Z-plane of the radial flow chamber LN model.

Techniques Used: Shear, Generated



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COMSOL Inc shear stress simulation plots
Lymph Fluid Flow Profiles Were Estimated in Quiescent and Remodeled LNs To model the affect of lymphatic remodeling or inflammation on the ability of a circulating cell to adhere to SCS-lining cells (A), a simplified geometric model of an afferent lymphatic vessel leading into the LN SCS (B) was imported into COMSOL to perform fluid flow simulations quantifying the wall <t>shear</t> <t>stress</t> (WSS) profile along the SCS floor (solid line) (C). This COMSOL-generated WSS estimation was in close agreement to the analytical solution for WSS profiles in a radial flow chamber (dashed line). (D–G) The analytically calculated ranges of WSS levels for (D, F) human or (E, G) mouse LNs based on maximum and minimum literature cited parameters for (D, E) volumetric flow rate or (F, G) SCS height. (H and I) COMSOL shear stress <t>simulation</t> <t>plots</t> along the (H) floor of the subcapsular sinus or (I) Z-plane of the radial flow chamber LN model.
Shear Stress Simulation Plots, supplied by COMSOL Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/shear+stress+simulation+plots/pmc07672279-68-64-63?v=COMSOL+Inc
Average 90 stars, based on 1 article reviews
shear stress simulation plots - by Bioz Stars, 2026-06
90/100 stars
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Lymph Fluid Flow Profiles Were Estimated in Quiescent and Remodeled LNs To model the affect of lymphatic remodeling or inflammation on the ability of a circulating cell to adhere to SCS-lining cells (A), a simplified geometric model of an afferent lymphatic vessel leading into the LN SCS (B) was imported into COMSOL to perform fluid flow simulations quantifying the wall shear stress (WSS) profile along the SCS floor (solid line) (C). This COMSOL-generated WSS estimation was in close agreement to the analytical solution for WSS profiles in a radial flow chamber (dashed line). (D–G) The analytically calculated ranges of WSS levels for (D, F) human or (E, G) mouse LNs based on maximum and minimum literature cited parameters for (D, E) volumetric flow rate or (F, G) SCS height. (H and I) COMSOL shear stress simulation plots along the (H) floor of the subcapsular sinus or (I) Z-plane of the radial flow chamber LN model.

Journal: iScience

Article Title: Lymph Node Subcapsular Sinus Microenvironment-On-A-Chip Modeling Shear Flow Relevant to Lymphatic Metastasis and Immune Cell Homing

doi: 10.1016/j.isci.2020.101751

Figure Lengend Snippet: Lymph Fluid Flow Profiles Were Estimated in Quiescent and Remodeled LNs To model the affect of lymphatic remodeling or inflammation on the ability of a circulating cell to adhere to SCS-lining cells (A), a simplified geometric model of an afferent lymphatic vessel leading into the LN SCS (B) was imported into COMSOL to perform fluid flow simulations quantifying the wall shear stress (WSS) profile along the SCS floor (solid line) (C). This COMSOL-generated WSS estimation was in close agreement to the analytical solution for WSS profiles in a radial flow chamber (dashed line). (D–G) The analytically calculated ranges of WSS levels for (D, F) human or (E, G) mouse LNs based on maximum and minimum literature cited parameters for (D, E) volumetric flow rate or (F, G) SCS height. (H and I) COMSOL shear stress simulation plots along the (H) floor of the subcapsular sinus or (I) Z-plane of the radial flow chamber LN model.

Article Snippet: This COMSOL-generated WSS estimation was in close agreement to the analytical solution for WSS profiles in a radial flow chamber (dashed line). (D–G) The analytically calculated ranges of WSS levels for (D, F) human or (E, G) mouse LNs based on maximum and minimum literature cited parameters ( ) for (D, E) volumetric flow rate or (F, G) SCS height. (H and I) COMSOL shear stress simulation plots along the (H) floor of the subcapsular sinus or (I) Z-plane of the radial flow chamber LN model. We note that this highly simplistic approximation neglects several unique attributes of LN flows, though with reasonable justification for a first-order model. First, lymphatic flows are pulsatile in nature but would be expected to be governed by Poiseuille flow, given rates of lymphatic contraction, kinematic viscosity of lymph, and vessel/sinus sizes.

Techniques: Shear, Generated